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KMID : 0043320060290080685
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Archives of Pharmacal Research
2006 Volume.29 No. 8 p.685 ~ p.690
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Inhibitory Effect of Ginsenoside Rg5 and Its Metabolite Ginsenoside Rh3 in an Oxazolone-Induced Mouse Chronic Dermatitis Model
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Shin Yong-Wook
Bae Eun-Ah
Kim Dong-Hyun
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Abstract
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The effect of a main constituent ginsenoside Rg5 isolated from red ginseng and its metabolite ginsenoside Rh3 in a chronic dermatitis model was investigated. Ginsenosides Rg5 and Rh3 suppressed swelling of oxazolone-induced mouse ear contact dermatitis. These ginsenosides also reduced mRNA expressions of cyclooxygenase-2, interleukin (IL)-1β, tumor necrosis factor (TNF)-α and interferon (IFN)-γ. The inhibition of ginsenoside Rh3 was more potent than that of ginsenoside Rg5. These findings suggest that ginsenoside Rh3 metabolized from ginsenoside Rg5 may improve chronic dermatitis or psoriasis by the regulation of IL-1β and TNF-α produced by macrophage cells and of IFN-γ produced by Th cells.
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KEYWORD
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Ginsenoside Rg5, Ginsenoside Rh3, COX-2, IFN-γ, Psoriasis
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